Pharmaceutical drugs are often restricted by their low solubility in physiological conditions, physical and chemical instability, toxicity, and other properties. Physical instability, for example, may cause modification of highly ordered protein structure, resulting in unwanted processes such as precipitation or aggregation.
Drug delivery polymers have played an important role in the development of drug delivery technologies by providing controlled release of therapeutic ingredients in constant doses over long periods, cyclic dosage, and tunable release of both hydrophilic and hydrophobic drugs.
The goal of this study was to demonstrate the importance of GPC in the analysis of commercially available drug delivery materials. Herein, 6 drug delivery polymers, namely Eudragit RS and RL, Eudragit L and S, Ethylcellulose, Cellulose Acetate, Poly(lactic-co-glycolic acid), and a PAMAM dendrimer were analyzed by standardized Gel Permeation Chromatography (GPC), an analytical service offered at Jordi Labs.
